Research By Year


Beta-hydroxy-beta-methylbutyrate ingestion, Part I: effects on strength and fat free mass.

In this double-blind, randomized study with male weightlifters, either three or six grams of HMB were consumed per day. HMB improved body composition, increased peak muscle torques, and decreased plasma CPK after resistance training with no added benefit seen from consuming the higher level.

Nutritional supplementation of the leucine metabolite beta-hydroxy-beta-methylbutyrate (hmb) during resistance training.

Two double-blind randomized studies including males and females and trained and untrained weightlifters. Both studies showed that regardless of gender or prior training, HMB increases strength and minimizes muscle damage when combined with a four-week resistance-training program.

Effects of beta-hydroxy-beta-methylbutyrate on muscle damage after a prolonged run.

This double-blind randomized study in male and female runners showed that HMB reduced muscle damage after a prolonged run. Decreasing the amount of muscle damage caused by running may decrease the DOMS soreness many long-distance runners experience.

Beta-hydroxy-beta-methylbutyrate ingestion, part II: effects on hematology, hepatic and renal function.

In this eight-week double-blind, randomized study with male weightlifters consuming up to six grams of HMB per day was shown to have no adverse effects on measures of hematology and hepatic and renal function.

beta-hydroxy-beta-methylbutyrate (HMB) supplementation in humans is safe and may decrease cardiovascular risk factors.

This study reported a summary of safety data from nine double-blind, placebo-controlled, randomized clinical trials including both men and women and young and elderly adults.  HMB supplementation was shown to have no adverse or untoward effects. HMB supplementation was also shown to have positive effects on LDL cholesterol (-7.3 percent) and systolic blood pressure (-4.4 mm Hg).

HMB supplementation does not influence urinary testosterone

In this case study of six males taking HMB, the results demonstrated that HMB does not alter testosterone levels and infer that HMB acts through a mechanism other than testosterone.

Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind, placebo-controlled study.

AIDS patients, who had previously lost body weight, gained back body weight and improved body composition as well as increased T-cells and decreased viral load when they consumed a dietary supplement containing HMB, arginine, and glutamine in this eight-week clinical study.

ß-Hydroxy-ß-methylbutyrate (HMB) is produced in vivo in humans from leucine

HMB is produced from leucine in humans and increasing plasma leucine will increase the rate of appearance and amount of plasma HMB.

Effects of dietary ß-hydroxy-ß-methylbutyrate on body composition in collegiate football players

In this study HMB was shown to decrease body fat and improve body composition in these well-trained collegiate football players.

The effect of ß-hydroxy-ß-methylbutyrate supplementation on muscular strength in collegiate athletes during a strenuous exercise program

This study is another showing HMB supplementation improved body composition in a brief, strenuous exercise program in highly trained athletes.

In vitro effects of beta-hydroxy-beta-methylbutyrate (HMB) on cell-mediated immunity in fish.

HMB was an immunomodulator of fish lymphocytes. HMB increased induced lymphocyte proliferation as well as the respiratory burst and potential killing activities of the lymphocytes.

Effect of ß-hydroxy-ß-methylbutyrate (HMB) on muscle cathepsins and calpain activities during the post-dexamethasone recovery period in young rats

HMB decreased the activities of proteolytic enzymes activated by dexamethasone.