Research By Year


Body composition in 70-year-old adults responds to dietary beta-hydroxy-beta-methylbutyrate similarly to that of young adults.

This paper reports a double-blind, randomized study in elderly men and women participating in a weight training exercise program. In this 8-week study in older adults, HMB tended to increase muscle strength and improve body composition while significantly increasing fat loss.

Creatine and beta-hydroxy-beta-methylbutyrate (HMB) additively increase lean body mass and muscle strength during a weight-training program.

This study reported the effects of HMB and creatine in a double-blind, randomized study in weight-training males. The results showed that HMB combined with creatine supplementation results in even greater strength gains and improvements in body composition than either HMB or creatine supplementation alone.

HMB supplementation during resistance training in trained men

In this double-blind, randomized study in trained male athletes undergoing a weight-training program, HMB supplementation numerically increased strength and improved body composition; however, the gains were not significantly greater than those of the placebo group.

Effect of beta-hydroxy beta-methylbutyrate on the onset of blood lactate accumulation and V(O)(2) peak in endurance-trained cyclists.

This double-blind switchback study with HMB, leucine, and placebo showed that HMB supplementation increased the cyclists endurance as measured by VO2 peak and lactate threshold.

HMB kinetics and the influence of glucose ingestion in humans.

In 2 randomized trials the blood levels of HMB were examined after eight males took either HMB, HMB plus glucose, glucose alone, or placebo.  These metabolic studies showed that the half-life of HMB in plasma is about 2.5 hours and that up to 85 percent of the HMB ingested is retained in the body.  Simultaneous glucose ingestion did not affect the percentage of HMB retained.

Effects of hmb supplementation on ldl-cholesterol, strength and body composition of patients with hypercholesterolemia

In hypercholesterolemic men participating in an exercise program, HMB decreased LDL cholesterol by 28 percent as well as increasing strength and improving body composition.  No changes in LDL were seen in the placebo group.

Influence of HMB (beta-hydroxy-beta-methylbutyrate) on antibody secreting cells (ASC) after in vitro and in vivo immunization with the anti-Yersinia ruckeri vaccine of rainbow trout (Oncorhynchus mykiss).

HMB increased the number of antibody secreting cells (ASC) after vaccination utilizing both in vitro and in vivo vaccination techniques.

The leucine metabolite 3‐hydroxy‐3‐methylbutyrate (HMB) modifies protein turnover in muscles of laboratory rats and domestic chickens in vitro

HMB decreased muscle proteolysis in isolated rat and chicken muscle in vitro which confirms earlier observations of decreased protein degradation in humans undergoing strenuous exercise.