Research By Year


Dietary toxicity of calcium beta-hydroxy-beta-methyl butyrate (CaHMB).

A toxicity study in rats fed up to five percent HMB in the diet was conducted. The data showed that HMB at five percent of the diet can be considered the NOAEL (no observed adverse effect level). The intakes were 3.49 and 4.16 g HMB/kg body weight per day in male and female rats, respectively. (Like an average human consuming about 35 g per day)

Attenuation of proteolysis in skeletal muscle by HMB in muscle loss.

This study was conducted in a mouse model of cancer tumor growth. HMB was shown to maintain lean body mass and attenuate protein degradation through downregulation of the increased expression of key regulatory components of the ubiquitin-proteasome proteolytic pathway.  HMB also stimulated protein synthesis.

Supplementation with beta-hydroxy-beta-methylbutyrate (HMB) and alpha-ketoisocaproic acid (KIC) reduces signs and symptoms of exercise-induced muscle damage in man.

This counterbalanced, crossover study in 6 non-resistance trained males given either a placebo or HMB/KIC (3 grams HMB and 0.3 grams KIC) showed that his combination reduced exercise-induced muscle damage.

Beta-hydroxy-beta-Methylbutyrate and its use in athletics.

Studies reviewed showed HMB may be beneficial in increasing lean mass in a number of groups (AIDS and cancer patients as well as athletes). No study has shown adverse effects of HMB as have been seen with other supplement regimens.