Research By Year


Effects of six weeks of beta-hydroxy-beta-methylbutyrate (HMB) and HMB/creatine supplementation on strength, power, and anthropometry of highly trained athletes.

Subjects’ ethical backgrounds prevented this study from being conducted as a double-blind, placebo-controlled study; however, a placebo treatment was utilized.  Using skin-fold data reported in this paper, results demonstrated a numerical improvement in body composition with HMB supplementation. This calculation was however not reported in the paper.

Beta-hydroxy-beta-methylbutyrate supplementation in critically ill trauma patients.

This placebo-controlled, double-blind clinical study of HMB in critically injured patients suggests that HMB can improve nitrogen balance in severely injured trauma patients.

ß-Hydroxy-ß-methylbutyrate. In J.A. Driskell (Ed.) Sports Nutrition: Fats and Proteins

This chapter in the CRC series of desk references for professional nutritionists and trainers discusses the origins, mechanisms, uses, safety, and results of HMB supplementation in both healthy individuals and those experiencing unwanted muscle loss.

Effects of beta-hydroxy-beta-methylbutyrate on aerobic-performance components and body composition in college students.

In this placebo-controlled study in interval-training college students, HMB supplementation was shown to significantly increase maximal oxygen consumption and respiratory compensation point.

Signaling pathways initiated by beta-hydroxy-beta-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli.

Protein synthesis studies were conducted in a cachectic mouse model and in muscle cell cultures.   The results demonstrate that HMB simulates protein synthesis in muscle by multiple mechanisms including the mTOR/p70S6k pathway.  Many of these mechanisms are also shared with leucine. However, HMB is more potent than leucine in attenuating the development of cachexia and is better tolerated by oral administration.

Emerging therapies to treat frailty syndrome in the elderly.

This review paper discusses dietary supplement and exercise interventions for fraility syndrome in the ederly.  Fraility syndrome is a major predictor of decreased health, well-being, and longevity in the elderly. HMB and Vitamin D are the only supplements reviewed in this paper that have been shown to improve strength and balance in randomized, placebo-controlled studies with elderly subjects.