Most supplement research looks at one ingredient at a time: does creatine work? Does beta-alanine work? That’s useful, but it’s not how most people supplement.

People are typically looking for a stack or regimen that will maximize results. Also, your workouts challenge your body in several ways at once, and an ingredient that helps with one thing may not touch another bottleneck that’s holding you back. So, I decided to put together strategic pairings that may help target these gaps more precisely.

The five pairings in this article each combine ingredients that complement each other. Sometimes they support the same process from different angles. Sometimes they cover different weak points that both matter during the same type of training. None of them require each other to work; they’re more like “better together” combinations. I also considered practicality. If the timing, dosing, or pill burden of the ingredients made a pairing annoying to actually use, I didn’t pair them.

One caveat worth being upfront about: direct research testing these exact duos together is rare. The reasoning behind each pairing is built on complementary mechanisms and shared training goals, not combination trials. Where direct data exists, I’ve noted it; where it doesn’t, I’ve explained why I think the pairing still holds up. The article is in two parts. The first covers the physiology these pairings are designed to influence, and the second walks through each pairing with dosing, evidence, and honest expectations.

Part One: What’s Happening Inside Your Muscles (and Why It Matters) 

Before diving into specific supplements, I want to walk through what you’re actually trying to influence inside muscle. The processes below were prioritized based on three things: 

1. How often each process becomes a real-world performance bottleneck 
2. How realistically it can be shifted through supplementation 
3. How important they are to protect or maintain for individuals between the ages of 30-60 

Think of these as the physiological “lever points”; the places where a well-chosen supplement strategy can plausibly move the needle on your training, even when your nutrition is already solid. If you want to dive deeper into these pairings, please proceed. If you want to go straight to the pairings, you have my permission to jump to Part 2! 

1. Building and Maintaining Muscle Tissue 

Your muscles constantly break down proteins and build new ones. Whether you gain or hold onto muscle depends on the balance between those two processes. How strongly muscle responds to the “build” signal from training and protein intake is called anabolic responsiveness. As you get older, that response begins to dampen, making it one of the most important constraints on muscle maintenance as you age. This build-versus-breakdown balance is also one of the most adjustable muscle processes through supplementation, even when you’re not dealing with any nutritional shortfall²¹. 

2. Speed, Explosiveness, and How Quickly You Can Produce Force 

For adults in this age bracket, the quality most people notice slipping first isn’t how much they can lift, it’s how quickly and explosively they can move. Muscle power (the combination of force and speed) declines earlier and more steeply than maximum strength with age, and the speed of muscle activation changes meaningfully between young, middle-aged, and older adults. Training itself drives the biggest gains here, but the factors that shape how well you express that ability on any given day can be influenced by targeted supplementation, even in non-deficient adults. This matters because how well you perform today drives how well you adapt over time²⁷. 

3. Your Muscles’ Rapid Energy System 

When you explode out of the bottom of a squat or power through the first reps of a heavy set, the energy comes primarily from phosphocreatine (PCr), a fast-acting reserve stored inside your muscle cells. PCr drops rapidly within a set and recovers mostly between sets, so it primarily determines the quality of each individual effort and whether your fourth set feels nearly as strong as your first. Glycogen, covered in the next section, becomes the bigger limiter across higher-volume sessions. How quickly muscles reload PCr between efforts is also a reliable indicator of overall muscular recovery capacity²⁹. This is one of the clearest examples of a process that can be meaningfully augmented through supplementation, creatine being the most well-known example. 

4. Sustaining Hard Efforts: Fuel Supply and Managing the Burn 

For most trainees, the real limiter isn’t a single all-out effort, it’s maintaining quality across many hard sets. Your muscles store carbohydrates as glycogen, and resistance training measurably drains that supply (about ~20% on average). When stores get low, volume and quality suffer¹⁴. At the same time, high-intensity work produces acidic byproducts—the familiar “burn”—and your body’s natural buffering systems have limits⁶. Both the fuel side and the buffering side can be meaningfully improved through supplementation. This article will focus on the buffering aspect of sustaining hard efforts. 

5. The Between-Efforts Recovery Engine 

This is one you may feel as the week goes on. It’s the difference between crisp reps on Monday and grinding through Thursday. Your mitochondria, the energy-producing structures inside each muscle cell, power recovery between sets and sessions by reloading phosphocreatine, clearing metabolic waste, and determining how much training volume you can handle before quality drops. The supply lines that keep this recovery engine fueled are the small blood vessels feeding your muscles—the microvascular network. Age-related changes to this internal energy system are meaningful contributors to performance losses over time. This system responds to supplementation in non-deficient adults, though effects tend to be more modest than what you see with rapid energy or buffering strategies. However, it still qualifies as a high-value target because it influences training repeatability, the unsung driver of long-term progress²⁹. 

6. Turning Electrical Signals into Muscle Force 

The force you produce on any given rep partially depends on the release of calcium inside the cell—it’s the chemical “on switch” that lets your muscle’s contractile machinery generate force. When you’re fatigued, that force-generating system is one of the first things to falter, contributing substantially to the force loss you experience during hard training². Aging also appears to alter calcium channels and related machinery, gradually reducing the capacity to generate and regenerate force. These changes become more pronounced later in life but meaningful changes occur before then⁹. Some supplementation strategies can influence how well this signal-to-force conversion works under stress, making it a legitimate target even without a nutritional deficiency. 

7. Recovering from Muscle Damage After Hard Training 

New exercises, heavy eccentric work (the lowering portion of lifts) or simply pushing harder than your muscles are accustomed to can produce several days of reduced force output, soreness, and impaired function. These factors directly affect how often and how well you can train in the days that follow⁷. Aging does not inevitably mean more damage or worse recovery, but the combination of age, training background, overall stress, and workload novelty can meaningfully shape recovery needs¹². Supplementation can influence the timeline of damage and repair in well-nourished adults, but I want to flag an important nuance: more suppression isn’t automatically better; the inflammatory process is part of how muscles rebuild, and blunting it indiscriminately could compromise the adaptations you’re training for²². 

Part Two: The Supplement Pairings 

Before getting into the pairings themselves, I made two deliberate omissions: creatine and caffeine. I left them out because both pair well with almost anything, and if you’re reading an article like this, I’m guessing you’re already taking one or both. I wanted to spotlight other ingredients. One other ground rule: every ingredient was chosen to have a plausible effect even when your diet is adequate and your nutrient levels (vitamin D, magnesium, iron, and so on) are already in good shape.

Pairing 1: Beetroot (Dietary Nitrate) + Citrulline 

Target Lever Points: The Between-Efforts Recovery Engine; Sustaining Hard Efforts 

Mechanisms and Rationale 

This is a “performance expression plus repeatability” pairing built around blood-flow physiology. The key molecule is nitric oxide (NO), which relaxes blood vessels, improves blood flow to working muscles, and helps deliver oxygen and nutrients while clearing waste products. Your body makes it through two distinct pathways, and this pairing feeds both. 

Beetroot provides nitrate, which your body converts to NO through a pathway that operates independently of the enzyme your body also uses to produce it. Citrulline takes the other route: it gets converted to arginine, which is the direct raw material for that enzyme. By feeding both pathways, you’re supporting NO production from two independent directions.

Practically, this is a stimulant-free pre-workout strategy aimed at making hard sets feel less “expensive”: better set quality, lower perceived strain, and improved ability to repeat high-quality efforts across an entire session. 

Evidence and Expectations 

When benefits show up in research, they tend to appear as more reps at a given effort level rather than dramatic jumps in peak strength. For beetroot, multiple trials in resistance-trained adults show modest improvements in submaximal lifting performance, though results can vary by exercise^{24, 30}. For citrulline, the pattern is similar: improved rep performance and reduced soreness across trials in both trained men and women, with emerging evidence that sustained daily dosing may outperform single pre-workout doses^3, 13, 23. The realistic expectation is hard sets that feel slightly less expensive—not PRs. 

Best-Use Scenarios 

The evidence is strongest when training density is the limiter: muscle-building phases with short-to-moderate rest periods, higher-rep compound movements, metabolically demanding sessions, or any training phase where the goal is to keep rep quality high across many sets. 

Dosing and Timing 

Beetroot/nitrate: Focus on the nitrate dose rather than the volume of juice, and allow enough lead time. Use a standardized beetroot juice shot providing approximately 400 mg of nitrate taken roughly 2 hours before exercise²⁴. 

Citrulline: The standard acute protocol is 6–8 g of L-citrulline or 8 g of citrulline malate taken approximately 45–60 minutes before a session^3,13. 

Practical stacking: Take beetroot earlier (about 2–3 hours before training) and citrulline closer to the session (about 1 hour before) so they reach peak effectiveness without requiring you to take everything at once. 

Pairing 2: Beta-Alanine + HMB 

Target Lever Points: Sustaining Hard Efforts; Building and Maintaining Muscle Tissue 

Mechanisms and Rationale 

This is a “work capacity plus recovery” pairing intended to increase training volume and improve recovery from that volume.  

Beta-alanine works by increasing levels of a molecule called carnosine inside your muscle cells. Carnosine acts like an acid sponge. It soaks up the hydrogen ions that accumulate during hard sets (the chemistry behind “the burn”), which helps you sustain output during repeated high-intensity efforts.

HMB (β-hydroxy-β-methylbutyrate) is a metabolite of leucine; your body naturally produces small amounts when processing this amino acid. In supplemental doses, HMB works both sides of the protein turnover equation: it stimulates muscle protein synthesis through a signaling route that appears to be independent of how leucine itself triggers muscle building, while simultaneously suppressing protein breakdown through multiple pathways^{26, 32}. The practical upshot for athletes is less about building new tissue and more about protecting what you have—reducing muscle damage from hard training, blunting the inflammatory response, and recovering faster between sessions. 

Together, beta-alanine helps you produce a higher-quality training stimulus in sessions where the burn is part of what limits you, while HMB works to help you recover from that stimulus—reducing muscle damage markers and maintaining weekly training quality when recovery from demanding sessions is the bottleneck.

Evidence and Expectations 

For beta-alanine, expect modest but consistent gains in high-rep endurance. The research suggests roughly a 3–5% improvement in capacity for efforts lasting 1–4 minutes, which in practice means a rep or two more on sets where the burn is the limiter. The ISSN position stand confirms that beta-alanine requires chronic loading (not acute single dosing) and functions through buffering-related performance mechanisms³¹. 

For HMB, the strongest case in trained athletes is recovery from muscle damage. A meta-analysis of 10 randomized controlled trials found that 3 g per day significantly reduced blood markers of exercise-induced muscle damage following intense training²⁵. In practice, that could mean faster restoration of strength and improved readiness for the next session. A 12-week study in highly-trained combat sports athletes confirmed the pattern, showing favorable body composition and performance outcomes during demanding training blocks¹⁰. Body composition results are more variable—shorter studies around 3 weeks in trained populations often show null results11, while longer interventions tend to be more promising. The timeline matters: plan on at least 6 weeks of consistent use before expecting meaningful benefits²⁶. 

Best-Use Scenarios 

Where managing fatigue and recovery between sessions is the limiter, this pairing becomes most defensible: higher-volume muscle-building blocks, short-rest training, conditioning-style lifting, CrossFit or Hyrox-style sessions, and planned overreaching phases. HMB becomes particularly relevant during phases with high eccentric loading, new exercise variations, or unfamiliar movement patterns that would otherwise generate excessive muscle damage and compromise subsequent training quality. The 6+ week timeline for benefits in trained athletes means this is a “training block” commitment, not a single-session tool.

Dosing and Timing 

Beta-alanine: This one requires patient, daily loading; it does not work acutely. Typical dosing protocols are 4–6 g per day, split into smaller servings of roughly 1.6–2 g each, for at least 4 weeks. The harmless tingling sensation some people feel (called paresthesia) can be reduced by using smaller split doses or sustained-release tablets. Taking it with meals may further support muscle carnosine buildup over time³¹. 

HMB: The standard protocol is 3 g per day (approximately 38 mg/kg of body weight), which can be split into three 1 g servings throughout the day or consolidated around training. HMB comes in two forms: HMB-FA (free acid) peaks in the bloodstream around 30–60 minutes post-ingestion, making it well-suited for a pre-workout dose. HMB-Ca (calcium salt) peaks closer to 2 hours, so plan accordingly. Maintain daily dosing throughout the entire training block—benefits in trained athletes typically emerge after 6 or more weeks of consistent use, though muscle damage protection may appear sooner^10, 26. 

Pairing 3: Tart Cherry Extract + Quercetin 

Target Lever Points: Recovering from Muscle Damage After Hard Training 

Mechanisms and Rationale 

This is a plant-compound recovery stack aimed at faster restoration of function after training that causes meaningful muscle damage, which means getting your strength and power back, reducing soreness, and improving how recovered you feel between workouts.

Tart cherry is rich in anthocyanins (the pigments that give cherries their deep red color), which have well-documented anti-inflammatory and antioxidant properties. Quercetin is a flavonoid—a different class of plant compound found in onions, apples, and berries—with its own anti-inflammatory profile. Their effects overlap but aren’t identical. That’s the point—broader coverage of the inflammatory and oxidative stress pathways involved in muscle damage and repair. The most defensible use case is targeted recovery support when soreness or strength loss would otherwise interfere with your training schedule.

Evidence and Expectations 

Both have been tested in resistance-trained populations with controlled, placebo-matched designs. Powdered tart cherry taken around a high-volume squat session reduced soreness and helped preserve strength-related measures versus placebo¹⁶. Quercetin, tested using a controlled muscle-damage protocol, improved the recovery of muscle function on a similar timeline⁴. The realistic expectation is faster return to baseline—less soreness and closer-to-normal strength—rather than complete prevention of damage. Often that means feeling ready to train hard again a day or so sooner. 

Best-Use Scenarios 

As a short-term tool, this pairing is most defensible during high-eccentric phases (new exercises, coming back from a layoff, heavy emphasis on the lowering portion of lifts), periods where multi-day performance loss is unacceptable (busy weeks, travel, compressed training schedules), or competition and event weekends where fast turnaround matters more than maximizing the long-term training signal.

Dosing and Timing 

Tart cherry: Protocols vary by form. An evidence-based capsule protocol used 480 mg per day of powdered tart cherry with breakfast for 7 days before, the day of, and 2 days after a damaging lower-body session—10 days total¹⁶. 

Quercetin: A common protocol is 1,000 mg per day, split into 500 mg twice daily, for approximately 1–2 weeks covering the damaging session and the recovery window⁴. 

Practical implementation: Begin both several days before a known demanding block (or immediately at its start) and continue through approximately 48–72 hours after the key sessions. Treat these as targeted, short-course tools rather than permanent daily supplements. 

Pairing 4: Taurine + Oral ATP 

Target Lever Points: Turning Electrical Signals into Muscle Force; The Between-Efforts Recovery Engine 

Mechanisms and Rationale 

This is a “power output plus fatigue resistance” pairing designed to improve training quality during high-intensity work. The practical translation: more power, better set quality, lower perceived effort, and faster recovery of function.

Taurine is an amino acid found in high concentrations in muscle tissue. Its most relevant value here is influencing how well your muscles function under stress—both acutely during a session and during the recovery period afterward. Mechanistically, taurine seems to help keep that calcium “on switch” for contraction working smoothly and the muscle fiber environment steadier when training gets ugly—so your signal-to-force output holds up a little better as fatigue builds.

Interestingly, oral ATP isn’t a way to ‘top off’ the ATP inside your muscles; it’s unlikely to directly raise intramuscular ATP stores. The leading explanation is signaling: ATP-related pathways may amplify the normal exercise cue that tells blood vessels to relax (vasodilate), which can translate into greater post-exercise blood flow and a better recovery environment between hard bouts¹⁵. 

Evidence and Expectations 

The acute case for taurine is promising: a single pre-session dose improved peak power output and reduced perceived effort in elite speed skaters⁵. Recovery data exists too—repeated dosing after a damaging session improved muscle function versus placebo¹⁹. Zooming out, a meta-analysis of 23 randomized trials found small-to-moderate performance improvements from a single taurine dose, with benefits more apparent in strength/power and endurance tasks than in tasks with anaerobic capacity and muscular endurance components⁸. 

For oral ATP, 400 mg per day during a 12-week periodized resistance program in trained men resulted in greater strength and lean mass gains and appeared to protect performance during a planned overreaching phase—a deliberate period of excessive training stress³³. Across the available trials, ATP’s most consistent benefit is supporting maximum strength gains, with more variable findings for power and rep performance. 

Best-Use Scenarios 

Where the limiter is maintaining output quality—both within a session and across a demanding block—this pairing is most defensible. Taurine’s acute performance and effort-reduction benefits suit high-intent days: heavy compounds, speed work, or sessions where bar velocity matters. ATP adds a longer arc, with its strength-preservation signal making the combination relevant during planned overreaching phases, peaking blocks, or high-frequency programs.

Dosing and Timing 

Taurine: For most people, the most practical approach is 3g about 60 minutes pre-workout on key training days. If you want to mirror the highest single-dose athlete data, use 6g pre-session occasionally for priority sessions. For recovery after unusually muscle-damaging training, use a short course of 3g twice daily for 2–3 days 

Oral ATP: 400 mg taken 30 minutes before training on workout days. Maintain daily use throughout the training block rather than treating ATP as a one-off pre-workout³³. 

Pairing 5: Ubiquinol CoQ10 + Urolithin A 

Target Lever Points: The Between-Efforts Recovery Engine 

Mechanisms and Rationale 

This is a mitochondria-focused pairing aimed at the between-efforts recovery engine: energy production inside muscle cells, reloading rapid energy stores, and overall capacity to handle training volume and recovery between sessions. These compounds support mitochondrial health from different angles.

Coenzyme Q10 (CoQ10) is a molecule that sits inside your mitochondria and plays a critical role in the chain of chemical reactions that produces energy (ATP). It also helps manage oxidative stress, the cellular wear and tear that comes with high energy production.

Urolithin A takes a different approach. Instead of directly supporting the energy production line, it activates a quality-control process called mitophagy. Essentially, mitophagy is your cells’ system for identifying damaged or underperforming mitochondria and recycling them so new, healthy ones can take their place. Think of CoQ10 as keeping your existing engines running smoothly, and urolithin A as replacing the engines that aren’t pulling their weight.

Evidence and Expectations 

Human performance data exist for both. In well-trained firefighters, two weeks of CoQ10 at 200 mg per day showed increases in average load and repetitions, with a general trend toward lower perceived exertion²⁰. A separate trial in trained Olympic athletes found 300 mg per day for 6 weeks improved peak power output versus placebo¹. 

For urolithin A, a 4-month trial in middle-aged adults found improved muscle strength at 500–1,000 mg per day, though peak power output did not significantly improve versus placebo²⁸. Other trials fill in the picture: in older adults, urolithin A improved muscle endurance and mitochondrial health markers¹⁷, and in resistance-trained male athletes, 1,000 mg per day for 8 weeks improved maximum force production and reps-to-failure versus placebo³⁴. 

Best-Use Scenarios 

If your limiter is repeatability and recovery capacity rather than single-effort peak strength, this is where the pairing is most defensible: higher-frequency training programs, high-density work, or anyone who feels they “run out of legs” as the training week goes on. 

Expect gradual improvements in how recovered you feel between sessions and how well you maintain output across a training week. The available data show effects like more reps at a given load, improved force production, and lower perceived effort—but these tend to emerge over 8+ weeks, not overnight.

Dosing and Timing 

CoQ10: 200–300 mg per day is the most evidence-supported range from performance studies. CoQ10 can have poor absorption, so make sure to use a product that ensures its usability. Look for products that use dispersion or liposomal delivery systems. You should be able to find this on the label. To further ensure absorption, take it with meals that contain some fat and consider splitting into 100 mg servings¹⁸. 

Urolithin A: 1,000 mg per day is the most common performance-relevant dose, often split into two daily doses with meals. 

Duration: If the goal is genuine performance and readiness improvements rather than just how you feel on a given day, plan on at least approximately 8 weeks. The trials in older and middle-aged adults studying mitochondrial outcomes extended to 12–16 weeks. 

Final Takeaways 

Strategic stacking works best when it’s built around real constraints, not hype. The pairings in this article are meant to be practical “better together” combinations that map to specific lever points inside muscle: rapid energy, buffering capacity, recovery, contractile signaling, and the ability to repeat high-quality efforts across a training week. Since direct combination trials are rare, the most honest way to use a framework like this is to pick one pairing that fits your current training goal, run it consistently for a full block, and judge it by measurable outcomes (set quality, repeatability, soreness timeline, and performance drift across the week).  

When you do choose ingredients, quality matters as much as the concept. That’s where branded ingredients can help, because they’re typically backed by defined specifications, quality standards, and a research trail you can actually trace. myHMB® is TSI Group’s HMB branded ingredient, developed to support muscle recovery and maintenance, and PEAK ATP® is TSI Group’s ATP branded ingredient, studied for its role in training performance and output.  

About TSI Group 

TSI Group is a science-driven global company focused on research, discovery, and the development of nutritional ingredients and health solutions. Beyond supplying ingredients, TSI Group supports brand partners through the full path from innovation and validation to commercialization—helping translate credible science into products people can use consistently to improve overall health. 

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References 

1. Alf, D., Schmidt, M. E., & Siebrecht, S. C. (2013). Ubiquinol supplementation enhances peak power production in trained athletes: A double-blind, placebo controlled study. Journal of the International Society of Sports Nutrition, 10, 24. https://pmc.ncbi.nlm.nih.gov/articles/PMC3661336/  
2. Allen, D. G., Lamb, G. D., & Westerblad, H. (2008). Skeletal muscle fatigue: Cellular mechanisms. Physiological Reviews, 88(1), 287–332. https://doi.org/10.1152/physrev.00015.2007  
3. Bayat, D., Azizi, M., Behpour, N., & Tinsley, G. M. (2025). Changes in resistance training performance, rating of perceived exertion, and blood biomarkers after six weeks of supplementation with L-citrulline vs. L-citrulline DL-malate in resistance-trained men: A double-blind placebo-controlled trial. Journal of the International Society of Sports Nutrition, 22(1), 2513944. https://doi.org/10.1080/15502783.2025.2513944  
4. Bazzucchi, I., Patrizio, F., Ceci, R., Duranti, G., Sgrò, P., Sabatini, S., Di Luigi, L., & Sacchetti, M. (2020). Quercetin supplementation improves neuromuscular function recovery from muscle damage. Nutrients, 12(9), 2850. https://doi.org/10.3390/nu12092850  
5. Buzdağlı, Y., Eyipınar, C. D., Öget, F., Şıktar, E., Forbes, S. C., & Tekin, A. (2023). Taurine supplementation enhances anaerobic power in elite speed skaters: A double-blind, randomized, placebo-controlled, crossover study. Biology of Sport, 40(3), 741–751. https://doi.org/10.5114/biolsport.2023.119990  
6. Cairns, S. P. (2006). Lactic acid and exercise performance: Culprit or friend? Sports Medicine, 36(4), 279–291. https://doi.org/10.2165/00007  
7. Clarkson, P. M., & Hubal, M. J. (2002). Exercise-induced muscle damage in humans. American Journal of Physical Medicine & Rehabilitation, 81(11 Suppl), S52–S69. https://doi.org/10.1097/00002060-200211001-00007  
8. Deng, H., Song, T., Yin, M., Xu, K., Zhong, Y., Liu, P., Sun, S., Naharudin, M. N. B., Yusof, A., & Fan, X. (2025). Does one shot work? The acute impact of a single taurine dose on exercise performance: A meta-analytic review. Scandinavian Journal of Medicine & Science in Sports, 35(9), e70123. https://doi.org/10.1111/sms.70123 
9. Dong, M., & Maturana, A. D. (2025). Effects of aging on calcium channels in skeletal muscle. Frontiers in Molecular Biosciences, 12, 1558456. https://doi.org/10.3389/fmolb.2025.1558456  
10. Durkalec-Michalski, K., Jeszka, J., & Podgórski, T. (2017). The Effect of a 12-Week Beta-hydroxy-beta-methylbutyrate (HMB) Supplementation on Highly-Trained Combat Sports Athletes: A Randomised, Double-Blind, Placebo-Controlled Crossover Study. Nutrients, 9(7), 753. https://doi.org/10.3390/nu9070753  
11. Durkalec-Michalski, K., Czlapka-Matyasik, M., Podgórski, T., Marchelek-Myśliwiec, M., & Nowaczyk, P. M. (2025). High-dose medium-term HMB supplementation did not trigger body composition changes in trained and untrained males under usual conditions or high-intensity functional exercise. Frontiers in Nutrition, 12, 1681465. https://doi.org/10.3389/fnut.2025.1681465  
12. Fernandes, J. F. T., Lamb, K. L., & Twist, C. (2019). Exercise-induced muscle damage and recovery in young and middle-aged males with different resistance training experience. Sports, 7(6), 132. https://pmc.ncbi.nlm.nih.gov/articles/PMC6628445/  
13. Glenn, J. M., Gray, M., Wethington, L. N., Stone, M. S., Stewart, R. W., Jr., & Moyen, N. E. (2017). Acute citrulline malate supplementation improves upper- and lower-body submaximal weightlifting exercise performance in resistance-trained females. European Journal of Nutrition, 56(2), 775–784. https://doi.org/10.1007/s00394-015-1124-6 
14. Hamidvand, A., Delleli, S., Rothschild, J. A., Chenaghchi, F., Jafari, A., & Naderi, A. (2025). Acute effects of resistance exercise on skeletal muscle glycogen depletion: A systematic review and meta-analysis. Physiological Reports, 13, e70683. https://doi.org/10.14814/phy2.70683 
15. Jäger, R., Roberts, M. D., Lowery, R. P., Joy, J. M., Cruthirds, C. L., Lockwood, C. M., Rathmacher, J. A., Purpura, M., & Wilson, J. M. (2014). Oral adenosine-5′-triphosphate (ATP) administration increases blood flow following exercise in animals and humans. Journal of the International Society of Sports Nutrition, 11, 28. https://doi.org/10.1186/1550-2783-11-28  
16. Levers, K., Dalton, R., Galvan, E., Goodenough, C., O’Connor, A., Simbo, S., Barringer, N., Mertens-Talcott, S. U., Rasmussen, C., Greenwood, M., Riechman, S., Crouse, S., & Kreider, R. B. (2015). Effects of powdered Montmorency tart cherry supplementation on an acute bout of intense lower body strength exercise in resistance trained males. Journal of the International Society of Sports Nutrition, 12, 41. https://doi.org/10.1186/s12970-015-0102-y  
17. Liu, S., D’Amico, D., Shankland, E., Bhayana, S., Garcia, J. M., Aebischer, P., Rinsch, C., Singh, A., & Marcinek, D. J. (2022). Effect of urolithin A supplementation on muscle endurance and mitochondrial health in older adults: A randomized clinical trial. JAMA Network Open, 5(1), e2144279. https://doi.org/10.1001/jamanetworkopen.2021.44279  
18. Mantle, D., & Dybring, A. (2020). Bioavailability of coenzyme Q10: An overview of the absorption process and subsequent metabolism. Antioxidants, 9(5), 386. https://pmc.ncbi.nlm.nih.gov/articles/PMC7278738/  
19. McLeay, Y., Stannard, S., & Barnes, M. (2017). The effect of taurine on the recovery from eccentric exercise-induced muscle damage in males. Antioxidants, 6(4), 79. https://doi.org/10.3390/antiox6040079  
20. Moreno-Fernandez, J., Puche-Juarez, M., Toledano, J. M., Chirosa, I., Chirosa, L. J., Pulido-Moran, M., Kajarabille, N., Guisado, I. M., Guisado, R., Diaz-Castro, J., & Ochoa, J. J. (2023). Ubiquinol short-term supplementation prior to strenuous exercise improves physical performance and diminishes muscle damage. Antioxidants, 12(6), 1193. https://doi.org/10.3390/antiox12061193  
21. Paulussen, K. J. M., McKenna, C. F., Beals, J. W., Wilund, K. R., Salvador, A. F., & Burd, N. A. (2021). Anabolic resistance of muscle protein turnover comes in various shapes and sizes. Frontiers in Nutrition, 8, Article 615849. https://doi.org/10.3389/fnut.2021.615849  
22. Peake, J. M., Neubauer, O., Della Gatta, P. A., & Nosaka, K. (2017). Muscle damage and inflammation during recovery from exercise. Journal of Applied Physiology, 122(3), 559–570. https://journals.physiology.org/doi/10.1152/japplphysiol.00971.2016  
23. Pérez-Guisado, J., & Jakeman, P. M. (2010). Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. Journal of Strength and Conditioning Research, 24(5), 1215–1222. 
24. Ranchal-Sanchez, A., Diaz-Bernier, V. M., Alonso de la Florida-Villagran, C., Llorente-Cantarero, F. J., Campos-Perez, J., & Jurado-Castro, J. M. (2020). Acute effects of beetroot juice supplements on resistance training: A randomized double-blind crossover. Nutrients, 12(7), 1912. https://doi.org/10.3390/nu12071912  
25. Rahimi, M. H., Mohammadi, H., Eshaghi, H., Askari, G., & Miraghajani, M. (2018). The effects of beta-hydroxy-beta-methylbutyrate supplementation on recovery following exercise-induced muscle damage: A systematic review and meta-analysis. Journal of the American College of Nutrition, 37(7), 640–649. https://doi.org/10.1080/07315724.2018.1451789  
26. Rathmacher, J. A., Pitchford, L. M., Stout, J. R., Townsend, J. R., Jäger, R., Kreider, R. B., Campbell, B. I., Kerksick, C. M., Harty, P. S., Candow, D. G., Roberts, B. M., Arent, S. M., Kalman, D. S., & Antonio, J. (2025). International society of sports nutrition position stand: β-hydroxy-β-methylbutyrate (HMB). Journal of the International Society of Sports Nutrition, 22(1), 2434734. https://doi.org/10.1080/15502783.2024.2434734  
27. Reid, K. F., & Fielding, R. A. (2012). Skeletal muscle power: A critical determinant of physical functioning in older adults. Exercise and Sport Sciences Reviews, 40(1), 4–12. https://doi.org/10.1097/JES.0b013e31823b5f13  
28. Singh, A., D’Amico, D., Andreux, P. A., Fouassier, A. M., Blanco-Bose, W., Evans, M., Aebischer, P., Auwerx, J., & Rinsch, C. (2022). Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine, 3(5), 100633. https://doi.org/10.1016/j.xcrm.2022.100633  
29. Singh, M., Jhajharia, A., Pruthi, R., & Carmichael, O. T. (2025). 31P-MRS-measured phosphocreatine recovery kinetics in human muscles in health and disease—A systematic review and meta-analysis. NMR in Biomedicine, 38(5), e70023. https://doi.org/10.1002/nbm.70023  
30. Tan, R., Pennell, A., Price, K. M., Karl, S. T., Seekamp, A. L., Lindsay, K. G., Price, M. J., & Jones, B. (2022). Beetroot juice ingestion improves bench press but not back squat performance in resistance trained adults. Nutrients, 14(18), 3703. 
31. Trexler, E. T., Smith-Ryan, A. E., Stout, J. R., Hoffman, J. R., Wilborn, C. D., Sale, C., Kreider, R. B., Jäger, R., Earnest, C. P., Bannock, L., Campbell, B., Kalman, D., Ziegenfuss, T. N., & Antonio, J. (2015). International Society of Sports Nutrition position stand: Beta-alanine. Journal of the International Society of Sports Nutrition, 12, 30. https://pmc.ncbi.nlm.nih.gov/articles/PMC4501114/  
32. Wilkinson, D. J., Hossain, T., Hill, D. S., Phillips, B. E., Crossland, H., Williams, J., Loughna, P., Churchward-Venne, T. A., Breen, L., Phillips, S. M., Etheridge, T., Rathmacher, J. A., Smith, K., Szewczyk, N. J., & Atherton, P. J. (2013). Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism. The Journal of Physiology, 591(11), 2911–2923. https://doi.org/10.1113/jphysiol.2013.253203 
33. Wilson, J. M., Joy, J. M., Lowery, R. P., Roberts, M. D., Lockwood, C. M., Manninen, A. H., Fuller, J. C., De Souza, E. O., Baier, S. M., Wilson, S. M. C., & Rathmacher, J. A. (2013). Effects of oral adenosine-5′-triphosphate supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained men. Nutrition & Metabolism, 10(1), 57. https://doi.org/10.1186/1743-7075-10-57   
34. Zhao, H., Zhu, H., Yun, H., Liu, J., Song, G., Teng, J., Zou, D., Lu, N., & Liu, C. (2024). Assessment of Urolithin A effects on muscle endurance, strength, inflammation, oxidative stress, and protein metabolism in male athletes with resistance training: an 8-week randomized, double-blind, placebo-controlled study. Journal of the International Society of Sports Nutrition, 21(1), 2419388. https://doi.org/10.1080/15502783.2024.241938