In this study the effects of HMB free acid supplementation and cold water immersion (CWI) on the expression of complement receptor type 3 (CR3) and the concentration macrophage inflammatory protein (MIP-1β) were studied after intense resistance exercise.  It was clear that both CWI and HMB free acid attenuated CR3 expression. While these were not correlated with an objective measure of improved recovery, the researchers concluded that HMB free acid modulates the inflammatory response, which could help the muscle recover faster.

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