HMB supplementation was given either pre- (60 min to allow blood levels to increase) or post-exercise to college-aged men performing acute isometric exercise by maximal voluntary contraction of the quadriceps and hamstrings.  Taking HMB pre-exercise prevented an increase in lactate dehydrogenase (LDH), an indicator of muscle damage. Therefore this study indicated there was an advantage to taking HMB pre-exercise.

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