In this review of data from studies supplementing HMB, 13 studies in healthy trained individuals, 11 studies in healthy untrained individuals, and 9 studies in patients with chronic diseases were examined.  The authors concluded that these studies demonstrated the HMB was effective in preventing muscle damage after exercise in both trained and untrained individuals, as well as in preventing muscle loss during chronic disease.  Additionally, the authors described the safety profile of HMB supplementation as “unequivocal”.