In this 12-week study, 35 subjects with the mean age of 79.1+7.5 years were examined to see how the nutritional intervention of HMB and Vitamin D would effect strength and quality of life. The results from the study confirm the beneficial effects on weight, handgrip strength, some domains of quality of life and Vitamin status of an enhanced enteral formula with Vitamin D and beta-hydroxy beta-methylbytyrate (HMB) in elderly patients.