Lipopolysaccharide (LPS) was used to simulate an endotoxemia model of muscle wasting in cultured muscle cells.  HMB was shown to attenuate the LPS-induced protein degradation. HMB attenuated the activation of caspase-3/-8, activation of dsRNA-dependant protein kinase, and production of reactive oxygen species.  This study further defined the mechanism whereby HMB may attenuate protein degradation in muscle wasting.

Back

Related Posts

Bench Press Speed Training

Heavy lifting can be difficult if you don’t have a training partner. Hall of fame powerlifter Brad Gillingham is here…

Read More