In this study, highly trained athletes were supplemented with either HMB alone, HMB plus creatine, or placebo. Researchers evaluated several health-related markers, including clinical blood chemistry and other indices of general health. The results showed no adverse changes in the measured health markers with HMB or HMB/creatine supplementation. The study suggests that HMB, alone or combined with creatine, was well tolerated in highly trained athletes during the study period.