In the pursuit of weight loss, maintaining muscle mass emerges as a critical factor for sustained success and quality of life.

Recent clinical findings shed light on the significant impact of muscle preservation on long-term weight management strategies, especially in the context of certain pharmacological interventions.

A noteworthy concern highlighted in recent studies is the potential adverse effects of rapid weight loss induced by glucagon-like peptide 1 (GLP-1) receptor agonists. While these drugs effectively promote fat loss, they may inadvertently lead to the loss of lean muscle mass, posing challenges to weight maintenance and overall health.

Contrary to popular belief, GLP-1s themselves do not directly cause muscle loss. Instead, their primary mechanism involves appetite suppression, often resulting in drastic calorie restriction. Consequently, the body resorts to breaking down both fat and muscle for energy, as evidenced by clinical trials demonstrating substantial losses in lean muscle mass alongside fat reduction.

This phenomenon raises significant concerns, particularly for older adults, who may already be grappling with age-related muscle decline. The implications of muscle loss extend beyond mere aesthetics, impacting metabolic efficiency, physical performance, and even independence.


a woman over 60 years old hugging herself and smiling in front of a tan background

How to Combat Muscle Loss Challenges

Amidst these challenges, emerging research highlights the potential of Calcium β-Hydroxy-β-methylbutyrate (HMB), commercially known as myHMB®, as a promising solution for muscle preservation. Human clinical studies indicate that HMB supplementation, particularly in conjunction with adequate protein intake and Vitamin D3, can effectively safeguard muscle mass, even in the absence of regular exercise.

Furthermore, HMB’s unique dual mechanism of action, facilitating muscle protein synthesis while inhibiting protein breakdown, underscores its efficacy in preserving lean muscle mass during periods of caloric restriction, such as intermittent fasting.


Muscle Health’s Role in Overall Health

Recognizing the critical role of muscle in maintaining metabolic health and facilitating sustainable weight management, experts emphasize the importance of prioritizing strategies that preserve muscle mass, especially in the context of weight loss interventions.

In conclusion, the findings from recent clinical studies underscore the indispensable role of muscle preservation in long-term weight management and overall well-being. As research continues to unravel the intricacies of muscle metabolism, innovative solutions like HMB offer promising avenues for promoting optimal muscle health and enhancing the efficacy of weight management strategies.

To read the full article on this topic please visit NutraIngredients USA.

Back To News