This paper reviews the first seven human studies with HMB and summarizes health and safety data generated as well as the muscle and strength gain data from these studies. The only significant changes in blood chemistry are decreases in total and LDL cholesterol.
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1997
Nutritional role of the leucine metabolite ß-hydroxy-ß-methylbutyrate (HMB)
Effect of feeding ß-hydroxy-ß-methylbutyrate (HMB) on body composition and strength of women
In two separate studies, one with and one without exercise, women were supplemented with HMB. No effect of HMB on body composition was measured in the non-exercising group of women, but in women undergoing exercise, HMB improved body composition and had increased fat loss, and strength gains.
Effect of ß-hydroxy-ß-methylbutyrate on the physiological response to exercise and conditioning in horses
HMB increased blood glucose and decreased blood triglycerides in response to conditioning.
The effect of intensive training and ß-hydroxy-ß-methylbutyrate (HMB) on the physiological response to exercise in horses
HMB supplementation to training horses increased endurance and aerobic metabolism as indicated by hematocrit and hemoglobin levels.
β-Hydroxy β-methyl butyrate increases fatty acid oxidation by muscle cells.
HMB increased fat oxidation in muscle cells.
