This paper describes a four-week, randomized, placebo-controlled study of 40 experienced resistance-trained males. In this study the trained athletes consumed either three or six grams of HMB per day. While not statistically significant, HMB consumption resulted in improved body composition and numerically greater strength gains.
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Effects of calcium beta-hydroxy-beta-methylbutyrate (HMB) supplementation during resistance-training on markers of catabolism, body composition and strength.
Changes in muscle soreness and strength following downhill running: Effects of creatine, HMB, and Betagen supplementation
HMB and Betagen (HMB and creatine) were the only supplements shown to decrease muscle soreness after downhill running, and HMB, creatine, and Betagen all decreased the loss in strength associated with the running.
Effect of the leucine metabolite ß-hydroxy-ß-methylbutyrate on muscle protein synthesis during prolonged bedrest
The trend for increased strength maintenance with HMB was not due to a change in muscle protein synthesis or whole-body protein turnover during periods of bed rest.
The effect of the leucine metabolite ß-hydroxy-ß-methylbutyrate on lean body mass and muscle strength during prolonged bedrest
Three grams of HMB per day tended to decrease the strength loss associated with extended periods of bed rest.
In vitro exposure with beta-hydroxy-beta-methylbutyrate enhances chicken macrophage growth and function.
HMB increased in vitro immune function in chicken macrophages.
Enhancement of cellular and humoral immunity in young broilers by the dietary supplementation of beta-hydroxy-beta-methylbutyrate.
HMB enhances cellular and humoral immunity in young broilers.