Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), L-arginine, and L-lysine.

In this year-long, double-blind, placebo-controlled study in the elderly, daily supplementation with HMB, arginine, and lysine resulted in improved body…

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Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review

This independent, peer-reviewed paper discusses the critical details of HMB studies and the variables affecting the results of these studies.…

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Beta-hydroxy-beta-methylbutyrate supplementation reduces tumor growth and tumor cell proliferation ex vivo and prevents cachexia in Walker 256 tumor-bearing rats by modifying nuclear factor-kappaB expression.

This 8-week study using a rat tumor model showed that oral HMB attenuated the cachexic weight loss caused by the…

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Mechanism of attenuation of muscle protein degradation induced by tumor necrosis factor-alpha and angiotensin II by beta-hydroxy-beta-methylbutyrate.

The author’s first paper detailed HMB effect on maintaining protein synthesis even after administration of lipopolysaccharide, TNF-α and angiotensin II.…

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